What are the side effects of moxonidine


Az előadások a következő témára: "A korszerű what are the side effects of moxonidine antitenzív kezelés szerepe a"— Előadás másolata: 1 A korszerű centrális antitenzív kezelés szerepe a kiemelt cardiovascularis kockázatú metabolikus szindrómás, Hypertoniás — Obes - Diabeteses betegcsoportokban Hypertension is an important cause of mortality and morbidity.

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It is now widely recognised that elevated blood pressure is frequently associated with obesity, insulin resistance and dyslipidaemia. One of the explanations for the association between raised blood pressure and co-morbidities of the metabolic syndrome is that they all reflect varying degrees of sympathetic overactivity.

Rahn KH et al. Oláh Csaba 2 H. Hypertonia Obesitas Diabetes Hypertension is an important cause of mortality and morbidity. J Hypertens ;17 suppl 3 :SS14 3 A tünetek különböző mértékű szimpatikus túlsúlyt tükröznek1 Metabolikus szindróma A hypertonia gyakran társul obezitással, inzulinrezisztenciával és dyslipidaemiával Ez a tünetegyüttes alkotja a metabolikus szindrómát, mely a diabetes és a cardiovascularis betegségek kialakulása szempontjából fokozott rizikót jelent Hypertension is an important cause of mortality and morbidity.

J Hypertens ;17 suppl 3 :SS14 A tünetek különböző mértékű szimpatikus túlsúlyt tükröznek1 1. J Hypertens ;17 suppl 3 :SS14 4 Szimpatikus túlsúly A fokozott szimpatikus tónus egy központi tényező, mely összekapcsolja a hypertoniát és a metabolikus szindróma egyéb komponenseit Sympathetic overactivity may be a central feature linking hypertension with other components of the metabolic Magas vérnyomás-adagolás.

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J Hypertens ;17 suppl 3 :SS14 2. J Hypertens ;17 suppl 3 :SS14 3. Mancia G et al. J Hum Hypertens ;11 suppl 1 :S3-S8.

Goldstein DS. Hypertension ; Julius S, Valentini M. Blood Press ;7 suppl 36.

A korszerű centrális antitenzív kezelés szerepe a - ppt letölteni

Scherrer U et al. Circulation ;7. Landsberg L. J Hypertens ;17 suppl 3 :SS14 8. Jamerson KA et al.

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Hypertension ;9. Huggett RJ et al.

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Circulation ; Valensi P et al. ESC Ritz E et al. Blood Press ;7 suppl 3 Haczynski J et al. J Clin Basic Cardiol ; Lanfranchi A et al. Elevated plasma insulin is a strong predictor of future diabetes, and sympathetic activation has been shown to be a major component of insulin resistance, both in clinical experiments[7] and in humans with type 2 diabetes.

Hypertension ; 8. Circulation ; 9.

mi csökkenti gyorsan a vérnyomást

ESC 7. Hypertension ;8. Circulation ;9.

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In this study, metabolic syndrome was defined as the presence of at least two of: obesity, hypertension, dyslipidaemia, microalbuminuria. Ref Isomaa B et al. Diabetes Care ; A metabolikus szindróma tünetei különböző mértékű szimpatikus túlsúlyt tükröznek2 1. Ref 9. Hypertoniás betegekben a moxonidin csökkenti a plazma glucose szintjét és fokozza az inzulin érzékenységet Prediabetic conditions such as insulin resistance, hyperinsulinaemia and hyperglycaemia may increase overall cardiovascular risk in patients with hypertension, especially when there are other risk factors associated with metabolic syndrome.

Long-term benefits of antihypertensive therapy may be compromised if the drugs chosen have adverse effects on insulin sensitivity. In hypertensive patients, moxonidine has been shown to reduce plasma glucose levels and increase insulin sensitivity. A placebo run-in period of weeks was followed by weeks of double-blind treatment with moxonidine 0. Therefore, in practice, moxonidine would not what are the side effects of moxonidine expected to cause unwanted hypoglycaemia in patients with normal blood glucose concentrations.

Haenni A, Lithell H. Almazov VA et al.

J Hypertens ;18 suppl 2 J Hypertens ;18 suppl 2 13 Inzulin-rezisztens hypertoniás betegek18 inzulin rezisztens, túlsúlyos, enyhe hypertoniás beteg, nyílt, randomizált vizsgálata 16 hetes moxonidin 2x0. This was an open, randomised, parallel group study in which moxonidine was compared with metformin a standard first-line oral hypoglycaemic agent in mildly hypertensive, insulin-resistant, overweight patients with impaired glucose tolerance or early type 2 diabetes.

In total, patients were randomised to receive either moxonidine 0.

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The area-under-the-curve AUC for insulin after a standard oral glucose tolerance test the primary endpoint was The difference between moxonidine and metformin was greater The insulin sensitivity index increased significantly to a similar extent in both treatment groups.

Betteridge J. There were no statistically significant differences between treatments in the change in insulin sensitivity from baseline. In this study, moxonidine was used as an adjunct to stable antihypertensive therapy, mostly ACE inhibitors, AIIAs, diuretics or calcium-channel blockers. Jacob S et al. Exp Clin Endocrinol Diabetes ; 6 : A large, double-blind, prospective study is currently in progress, which is designed to evaluate the effects of moxonidine and ramipril either as monotherapy or in combination in overweight patients with mild-to-moderate hypertension and impaired fasting glycaemia.

Exp Clin Endocrinol Diabetes ; 6 : 15 Obesitás és hypertonia Obes betegekben a hypertonia, a renalis szimpatikus idegek aktivációjával és a RAAS rendszer stimulációjával mutat összefüggést 20,21 Az emelkedett BMI, fokozott vizelet NA szinttel jár együtt22 Az normo,- és hypertoniás obes betegek többségében emelkedett a leptin szint23,24 Obesity is a major risk factor for the development of hypertension.

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It is one of the cluster of cardiovascular, renal, metabolic and neuro-endocrine disorders which make up the metabolic syndrome. Hypertension in obese patients appears to be related mainly to activation of renal sympathetic nerves and stimulation of the renin-angiotensin system. Over-eating in humans increases sympathetic nervous activity. In obese hypertensive patients, urinary norepinephrine levels increase with rising body mass index BMI and also with increasing abdominal fat distribution.

Most obese subjects and obese hypertensive patients have high circulatory leptin levels, even when leptin is corrected for BMI. This is because activation of the sympathetic nervous system not only contributes to elevated blood pressure but may also lead to unwanted metabolic and cardiovascular effects in these patients. Refs Hall JE. Am J Hypertens ; SS Tuck ML et al.

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N Engl J Med ; J Cardiovasc Pharmacol ;23 suppl 1 :S1-S8. Trace Elem Electrolytes ; Masuo K et al. Am J Hypertens ; N Engl J Med ; Barroso SG et al.

Trace Elem Electrolytes ; Following a 2-week washout period, patients were randomised to receive 0.

The total duration of active therapy was 24 weeks. Subjects maintained a usual intake of sodium and were not on a calorie-restricted diet.

Both drugs reduced office BP to a similar degree, and there was no statistically significant difference between them on hour blood pressure measurements. Neither drug was associated with any significant changes in heart rate during daytime or overnight. Sanjuliani AF et al. J Clin Basic Cardiol ; This finding probably reflects the heterogeneity of sympathetic activity in obese hypertensive patients.

The authors commented that the differences between drug treatments were seen despite using only a mid-range dose of moxonidine up to 0.

Minőségi műanyag nyílászárók: Moxonidine

This was an open, multicentre, observational study in primary care and included 25 patients with type 2 diabetes.

Patients also received a low calorie diet and were recommended to exercise daily. Abellán J et al. Kidney Int ;67 suppl 93 :SS24 Kidney Int ;67 suppl 93 :SS24 19 Postmenopausalis hypertonia Menopausa után a systolés vérnyomás emelkedése jellemző Menopausa után hölgyekben a hypertonia prevalenciája megegyezik a férfiakéval! Burt VL et al. Hypertension ; Tong PL et al.

Atherosclerosis ; 2 : Mercuro G et al.

[The Classics of Hypertonology 4. – Professor John H. Laragh, ] | csepeli-joszerencset-he.hu

Ital Heart J ; 2 10 : Hypertension ; Atherosclerosis ; 2 : The contribution of hormonal changes to increased blood pressure in postmenopausal women is unclear, but may include reduced elasticity of the arteries, reduced sensitivity of angiotensin II receptors, increased plasma renin activity, reduced nitric oxide activity, and increased sympathetic activity.

After the menopause there is a shift in the autonomic control of the cardiovascular system towards an increased sympathetic tone which is, in part, independent from changes in body weight and glucose metabolism, but is in the long-term heightened by these metabolic changes.

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The prevalence of metabolic syndrome in postmenopausal hypertensive women has important implications for therapy, as some antihypertensive drugs may worsen the already altered metabolic profile of these patients while others may have a beneficial effect.

The profile of moxonidine, with its what are the side effects of moxonidine effects on sympathetic outflow and glucose metabolism, suggests it should be particularly useful in treating hypertension in postmenopausal women with metabolic syndrome.

Sjoberg L et al.

Moxonidine is a medicine available in a number of countries worldwide.

A plazma glucose változása a kiindulási értékhez képest OGTT során moxonidin 0. Mean body mass index was A 4-week placebo run-in phase was followed by a double-blind 8-week therapy period.

Statistically significant reductions in systolic and diastolic blood pressure occurred in both treatment groups during the course of treatment, with the beta-blocker having a slightly more potent effect overall. Atenolol was associated with a significant decrease in heart rate